منابع مشابه
Fitness trade-offs in blaTEM evolution.
bla(TEM-1) expression results in penicillin resistance, whereas expression of many bla(TEM-1) descendants, called extended-spectrum beta-lactamases (ESBLs), results simultaneously in resistance to penicillins and extended-spectrum cephalosporins. Despite the expanded resistance phenotypes conferred by many ESBLs, bla(TEM-1) is still the most abundant bla(TEM) allele in many microbial population...
متن کاملHow evolution draws trade-offs
Recent empirical evidence suggest that tradeoff shapes can evolve, challenging the classica image of their high entrenchment. Here we model the evolution of the physiological mechanism that controls the allocation of resources to two traits, by mutating the expression and the conformation of its constitutive hormones and receptors. We show that trade-off shapes do indeed evolve in this model th...
متن کاملTrade-offs in parasitology, evolution and behavior.
Most animal pare,~ts find caring for offspring to be costly, whether in terms of increased vigilance against predators or higher grocery bills. Most parasitologists know that defense against pathogens is costly as well, requiring elaborate physiological and biochemical mechanisms to recognize and destroy the invader. In both cases, the parent or host can be seen as making a trade-off, allocatin...
متن کاملTrade-Offs in Life-History Evolution
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متن کاملFitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum
BACKGROUND Patterns of emerging drug resistance reflect the underlying adaptive landscapes for specific drugs. In Plasmodium falciparum, the parasite that causes the most serious form of malaria, antifolate drugs inhibit the function of essential enzymes in the folate pathway. However, a handful of mutations in the gene coding for one such enzyme, dihydrofolate reductase, confer drug resistance...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00018-08